This web page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison.
References
Introduction
1. Carroll SB (2005) Evolution at Two Levels: On Genes and Form. PLoS Biol 3(7):e245. PMID: 16000021
2. Enard W, Przeworski M, Fisher SE, Lai CSL, Kitano WV, et al. (2002) Molecular evolution of FOXP2, a gene involved in speech and language. Nature 418:869–872. PMID: 12192408
3. Vargha-Khadem F, Gadian DG, Copp A, Mishkin M (2005) FOXP2 and the neuroanatomy of speech and language. Nat Rev Neurosci 6:131–138. PMID: 15685218
4. Krause J, et al. (2007) The derived FOXP2 variant of modern humans was shared with Neandertals. Curr Biol 7(21):1908-12. PMID: 17949978
5. (Figure) Imaging Notes. Retrieved February 02, 2009 fromhttp://www.imagingnotes.com/go/article_free.php?mp_id=1&Udo
6. Guild AS and Vail T. What is Developmental Apraxia of Speech? Retrieved May 04, 2009 from http://www.tayloredmktg.com/dyspraxia/das.shtml
In the news...
1. Enard W, Przeworski M, Fisher SE, Lai CSL, Kitano WV, et al. (2002) Molecular evolution of FOXP2, a gene involved in speech and language. Nature 418:869–872. PMID: 12192408
2. Wong, K. (2002, August 15) Gene study explains chatty humans, speechless apes. <http://www.sciam.com/article.cfm?id=gene-study-explains-chatt>
In the literature...
1. Enard W, Przeworski M, Fisher SE, Lai CSL, Kitano WV, et al. (2002) Molecular evolution of FOXP2, a gene involved in speech and language. Nature 418:869–872. PMID: 12192408
News vs. Science
1. Enard W, Przeworski M, Fisher SE, Lai CSL, Kitano WV, et al. (2002) Molecular evolution of FOXP2, a gene involved in speech and language. Nature 418:869–872. PMID: 12192408
2. Wong, K. (2002, August 15) Gene study explains chatty humans, speechless apes. <http://www.sciam.com/article.cfm?id=gene-study-explains-chatt>
Gene Sequences... etc.
1. SMART (2009) FH domain annotation Retrieved February 28, 2009 from http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=FH&BLAST=DUMMY
2. SMART (2009) ZnF_C2H2 domain annotation Retrieved February 28, 2009 from http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=ZnF_C2H2&BLAST=DUMMY
3. Swofford, D.L. 2002. PAUP*. Phylogenetic Analysis Using Parsimony (*and Other Methods). Version 4. Sinauer Associates, Sunderland, Massachusetts.
4. Tree of Life Web Project (1995-2004) Eutheria Retrieved on February 28, 2009 fromhttp://tolweb.org/Eutheria/15997
5. NCBI (2009) Entrez Gene FOXP2 forkhead box P2 [Homo sapiens] Retrieved on February 28, 2009 fromhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=93986&ordinal
pos=2&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
Algorithm and sequence websites
TCOFFEE
NCBI
SMART
MOTIF
Phenotypes & GO
1. AmiGO (2009) AmiGO: caudate nucleus development Details Retrieved March 28, 2009 fromhttp://amigo.geneontology.org/cgi-bin/amigo/term-details.cgi?term=GO:0021757&session_id=6794amigo1238292543&
2. AmiGO (2009) AmiGO: putamen development Details Retrieved March 28, 2009 fromhttp://amigo.geneontology.org/cgi-bin/amigo/term-details.cgi?term=GO:0021758&session_id=6794amigo1238292543&3. Stroud JC, Wu Y, Bates DL, Han A, Nowick K,
3. Paabo S, Tong H, Chen L (2006) Structure of the forkhead domain of FOXP2 bound to DNA. Structure 14:159-166. PMID: 16407075
4. Vargha-Khadem F, Gadian DG, Copp A, Mishkin M (2005) FOXP2 and the neuroanatomy of speech and language. Nat Rev Neurosci 6:131–138. PMID: 15685218
5. Haesler S, Rochefort C, Georgi B, Licznerski P, Osten P, Scharff C (2007) Incomplete and innacurate vocal imitation after knockdown of FoxP2 in songbird basal ganglia nucleus area X. PLoS Biology 5:2885-2897. PMID: 18052609
Databases
GO Consortium
AmiGO
FlyBase
WormBase
Protein Data
1. Stroud JC, Wu Y, Bates DL, Han A, Nowick K, Paabo S, Tong H, and Chen L. (2006) Structure of the forkhead domain of FOXP2 bound to DNA. Structure 14:159-166. PMID: 16407075
2. Vernes SC, Spiteri E, Nicod J, Groszer M, Taylor JM, Davies KE, Geschwind DH, and Fisher SE. (2007) High-throughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disorders. Am J Hum Genet. 81:1232-1250. PMID: 17999362
Databases
EBI-PDBsum
EBI-RESID
ESLpred
ExPASy
SMART
Protein network
1. Homebox Genes Database (1994-2000) Engraied-2 Retrieved on April 26, 2009 from http://www.evol.nw.ru/labs/lab38/spirov/hox_pro/hox-pro00.html.
2. NCBI (February 4, 2009) Entrez Gene: CTBP1 C-terminal binding protein 1 [Homo sapiens] Retrieved April 26, 2009 from http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1487&ordinalpos=1&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
3. NCBI (February 4, 2009) Entrex Gene: NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 [Homo sapiens] Retrieved April 26, 2009 from http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4773&ordinalpos=1&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
4. NFATc-Down's Syndrome (2009) Retrieved April 26, 2009 from http://nollgen677s09.weebly.com/index.html
5. Shu W, Cho JY, Jiang Y, Zhang M, Weisz D, Elder GA, Schmeidler J, De Gasperi R, Sosa MA, Rabidou D, Santucci AC, Perl D, Morrisey E, and Buxbaum JD. (2005) Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene. PNAS 102:9643-9648 PMID: 15983371
Databases
STRING
Miscellaneous
1. Spiteri E, Konopka G, Coppola G, Bomar J, Oldham M, Ou J, Vernes SC, Fisher SE, Ren B, Geschwind DH (2007) Identification of transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain. Am J Hum Genet 81:1144-1157 PMID: 17999357
2. Vernes SC, Spiteri E, Nicod J, Groszer M, Taylor JM, Davies KE, Geschwind DH, Fisher SE (2007) High-throuhgput analysis of promoter occupancy reveals direct nueral targets of FOXP2, a gene mutated in speech and language disorders. Am J Hum Genet 81:1232-1250 PMID: 17999362
1. Carroll SB (2005) Evolution at Two Levels: On Genes and Form. PLoS Biol 3(7):e245. PMID: 16000021
2. Enard W, Przeworski M, Fisher SE, Lai CSL, Kitano WV, et al. (2002) Molecular evolution of FOXP2, a gene involved in speech and language. Nature 418:869–872. PMID: 12192408
3. Vargha-Khadem F, Gadian DG, Copp A, Mishkin M (2005) FOXP2 and the neuroanatomy of speech and language. Nat Rev Neurosci 6:131–138. PMID: 15685218
4. Krause J, et al. (2007) The derived FOXP2 variant of modern humans was shared with Neandertals. Curr Biol 7(21):1908-12. PMID: 17949978
5. (Figure) Imaging Notes. Retrieved February 02, 2009 fromhttp://www.imagingnotes.com/go/article_free.php?mp_id=1&Udo
6. Guild AS and Vail T. What is Developmental Apraxia of Speech? Retrieved May 04, 2009 from http://www.tayloredmktg.com/dyspraxia/das.shtml
In the news...
1. Enard W, Przeworski M, Fisher SE, Lai CSL, Kitano WV, et al. (2002) Molecular evolution of FOXP2, a gene involved in speech and language. Nature 418:869–872. PMID: 12192408
2. Wong, K. (2002, August 15) Gene study explains chatty humans, speechless apes. <http://www.sciam.com/article.cfm?id=gene-study-explains-chatt>
In the literature...
1. Enard W, Przeworski M, Fisher SE, Lai CSL, Kitano WV, et al. (2002) Molecular evolution of FOXP2, a gene involved in speech and language. Nature 418:869–872. PMID: 12192408
News vs. Science
1. Enard W, Przeworski M, Fisher SE, Lai CSL, Kitano WV, et al. (2002) Molecular evolution of FOXP2, a gene involved in speech and language. Nature 418:869–872. PMID: 12192408
2. Wong, K. (2002, August 15) Gene study explains chatty humans, speechless apes. <http://www.sciam.com/article.cfm?id=gene-study-explains-chatt>
Gene Sequences... etc.
1. SMART (2009) FH domain annotation Retrieved February 28, 2009 from http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=FH&BLAST=DUMMY
2. SMART (2009) ZnF_C2H2 domain annotation Retrieved February 28, 2009 from http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=ZnF_C2H2&BLAST=DUMMY
3. Swofford, D.L. 2002. PAUP*. Phylogenetic Analysis Using Parsimony (*and Other Methods). Version 4. Sinauer Associates, Sunderland, Massachusetts.
4. Tree of Life Web Project (1995-2004) Eutheria Retrieved on February 28, 2009 fromhttp://tolweb.org/Eutheria/15997
5. NCBI (2009) Entrez Gene FOXP2 forkhead box P2 [Homo sapiens] Retrieved on February 28, 2009 fromhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=93986&ordinal
pos=2&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
Algorithm and sequence websites
TCOFFEE
NCBI
SMART
MOTIF
Phenotypes & GO
1. AmiGO (2009) AmiGO: caudate nucleus development Details Retrieved March 28, 2009 fromhttp://amigo.geneontology.org/cgi-bin/amigo/term-details.cgi?term=GO:0021757&session_id=6794amigo1238292543&
2. AmiGO (2009) AmiGO: putamen development Details Retrieved March 28, 2009 fromhttp://amigo.geneontology.org/cgi-bin/amigo/term-details.cgi?term=GO:0021758&session_id=6794amigo1238292543&3. Stroud JC, Wu Y, Bates DL, Han A, Nowick K,
3. Paabo S, Tong H, Chen L (2006) Structure of the forkhead domain of FOXP2 bound to DNA. Structure 14:159-166. PMID: 16407075
4. Vargha-Khadem F, Gadian DG, Copp A, Mishkin M (2005) FOXP2 and the neuroanatomy of speech and language. Nat Rev Neurosci 6:131–138. PMID: 15685218
5. Haesler S, Rochefort C, Georgi B, Licznerski P, Osten P, Scharff C (2007) Incomplete and innacurate vocal imitation after knockdown of FoxP2 in songbird basal ganglia nucleus area X. PLoS Biology 5:2885-2897. PMID: 18052609
Databases
GO Consortium
AmiGO
FlyBase
WormBase
Protein Data
1. Stroud JC, Wu Y, Bates DL, Han A, Nowick K, Paabo S, Tong H, and Chen L. (2006) Structure of the forkhead domain of FOXP2 bound to DNA. Structure 14:159-166. PMID: 16407075
2. Vernes SC, Spiteri E, Nicod J, Groszer M, Taylor JM, Davies KE, Geschwind DH, and Fisher SE. (2007) High-throughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disorders. Am J Hum Genet. 81:1232-1250. PMID: 17999362
Databases
EBI-PDBsum
EBI-RESID
ESLpred
ExPASy
SMART
Protein network
1. Homebox Genes Database (1994-2000) Engraied-2 Retrieved on April 26, 2009 from http://www.evol.nw.ru/labs/lab38/spirov/hox_pro/hox-pro00.html.
2. NCBI (February 4, 2009) Entrez Gene: CTBP1 C-terminal binding protein 1 [Homo sapiens] Retrieved April 26, 2009 from http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1487&ordinalpos=1&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
3. NCBI (February 4, 2009) Entrex Gene: NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 [Homo sapiens] Retrieved April 26, 2009 from http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4773&ordinalpos=1&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
4. NFATc-Down's Syndrome (2009) Retrieved April 26, 2009 from http://nollgen677s09.weebly.com/index.html
5. Shu W, Cho JY, Jiang Y, Zhang M, Weisz D, Elder GA, Schmeidler J, De Gasperi R, Sosa MA, Rabidou D, Santucci AC, Perl D, Morrisey E, and Buxbaum JD. (2005) Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene. PNAS 102:9643-9648 PMID: 15983371
Databases
STRING
Miscellaneous
1. Spiteri E, Konopka G, Coppola G, Bomar J, Oldham M, Ou J, Vernes SC, Fisher SE, Ren B, Geschwind DH (2007) Identification of transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain. Am J Hum Genet 81:1144-1157 PMID: 17999357
2. Vernes SC, Spiteri E, Nicod J, Groszer M, Taylor JM, Davies KE, Geschwind DH, Fisher SE (2007) High-throuhgput analysis of promoter occupancy reveals direct nueral targets of FOXP2, a gene mutated in speech and language disorders. Am J Hum Genet 81:1232-1250 PMID: 17999362
